Diphenhydramine vs Naproxen

## Diphenhydramine vs Naproxen: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Naproxen**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Naproxen**: Non-selective COX inhibitor.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Naproxen — 12-17 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Naproxen — C14H14O3.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Naproxen — 230.2590 g/mol.

**Type**: Diphenhydramine — Small molecule; Naproxen — Small molecule.