Diphenhydramine vs Paroxetine

Diphenhydramine vs Paroxetine: Overview

This comparison examines the pharmacological differences between Diphenhydramine and Paroxetine.

Mechanism of Action

Diphenhydramine: First-generation H1 antihistamine with anticholinergic properties.

Paroxetine: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

Pharmacokinetics

Half-life: Diphenhydramine — 2-8 hours; Paroxetine — 21 hours.

Chemical Properties

Molecular Formula: Diphenhydramine — C17H21NO; Paroxetine — C19H20FNO3.

Molecular Weight: Diphenhydramine — 255.3550 g/mol; Paroxetine — 329.3730 g/mol.

Type: Diphenhydramine — Small molecule; Paroxetine — Small molecule.