Diphenhydramine vs Trazodone

## Diphenhydramine vs Trazodone: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Trazodone**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Trazodone**: Serotonin antagonist and reuptake inhibitor (SARI).

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Trazodone — 5-9 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Trazodone — C19H22ClN5O.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Trazodone — 371.8640 g/mol.

**Type**: Diphenhydramine — Small molecule; Trazodone — Small molecule.