Donepezil vs Paroxetine

Donepezil vs Paroxetine: Overview

This comparison examines the pharmacological differences between Donepezil and Paroxetine.

Mechanism of Action

Donepezil: Reversible acetylcholinesterase inhibitor.

Paroxetine: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

Pharmacokinetics

Half-life: Donepezil — 70 hours; Paroxetine — 21 hours.

Chemical Properties

Molecular Formula: Donepezil — C24H29NO3; Paroxetine — C19H20FNO3.

Molecular Weight: Donepezil — 379.4920 g/mol; Paroxetine — 329.3730 g/mol.

Type: Donepezil — Small molecule; Paroxetine — Small molecule.