Doxycycline vs Trimethoprim

Doxycycline vs Trimethoprim: Overview

This comparison examines the pharmacological differences between Doxycycline and Trimethoprim.

Mechanism of Action

Doxycycline: Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.

Trimethoprim: Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics

Half-life: Doxycycline — 18-22 hours; Trimethoprim — 8-10 hours.

Chemical Properties

Molecular Formula: Doxycycline — C22H24N2O8; Trimethoprim — C14H18N4O3.

Molecular Weight: Doxycycline — 444.4350 g/mol; Trimethoprim — 290.3180 g/mol.

Type: Doxycycline — Small molecule; Trimethoprim — Small molecule.