Duloxetine vs Sertraline

Duloxetine vs Sertraline: Overview

This comparison examines the pharmacological differences between Duloxetine and Sertraline.

Mechanism of Action

Duloxetine: Serotonin-norepinephrine reuptake inhibitor (SNRI).

Sertraline: Selective serotonin reuptake inhibitor (SSRI).

Pharmacokinetics

Half-life: Duloxetine — 12 hours; Sertraline — 26 hours.

Chemical Properties

Molecular Formula: Duloxetine — C18H19NOS; Sertraline — C17H17Cl2N.

Molecular Weight: Duloxetine — 297.4150 g/mol; Sertraline — 306.2290 g/mol.

Type: Duloxetine — Small molecule; Sertraline — Small molecule.