Duloxetine vs Tofacitinib

## Duloxetine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Tofacitinib**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Tofacitinib — C16H20N6O.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Duloxetine — Small molecule; Tofacitinib — Small molecule.