Duloxetine vs Trazodone

## Duloxetine vs Trazodone: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Trazodone**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Trazodone**: Serotonin antagonist and reuptake inhibitor (SARI).

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Trazodone — 5-9 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Trazodone — C19H22ClN5O.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Trazodone — 371.8640 g/mol.

**Type**: Duloxetine — Small molecule; Trazodone — Small molecule.