Durvalumab vs Methotrexate

## Durvalumab vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Durvalumab** and **Methotrexate**.

## Mechanism of Action

**Durvalumab**: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Durvalumab — 17 days; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Durvalumab — N/A; Methotrexate — C20H22N8O5.

**Molecular Weight**: Durvalumab — N/A; Methotrexate — 454.4400 g/mol.

**Type**: Durvalumab — Antibody; Methotrexate — Small molecule.