Durvalumab vs Tacrolimus

Durvalumab vs Tacrolimus: Overview

This comparison examines the pharmacological differences between Durvalumab and Tacrolimus.

Mechanism of Action

Durvalumab: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

Tacrolimus: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

Pharmacokinetics

Half-life: Durvalumab — 17 days; Tacrolimus — 12 hours.

Chemical Properties

Molecular Formula: Tacrolimus — C44H69NO12.

Molecular Weight: Tacrolimus — 804.0180 g/mol.

Type: Durvalumab — Antibody; Tacrolimus — Small molecule.