Erlotinib vs Osimertinib

Erlotinib vs Osimertinib: Overview

This comparison examines the pharmacological differences between Erlotinib and Osimertinib.

Mechanism of Action

Erlotinib: Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

Osimertinib: Third-generation irreversible EGFR TKI targeting T790M resistance mutation and activating mutations.

Pharmacokinetics

Half-life: Erlotinib — 36 hours; Osimertinib — 48 hours.

Chemical Properties

Molecular Formula: Erlotinib — C22H23N3O4; Osimertinib — C28H33N7O2.

Molecular Weight: Erlotinib — 393.4380 g/mol; Osimertinib — 499.6050 g/mol.

Type: Erlotinib — Small molecule; Osimertinib — Small molecule.