Esomeprazole vs Omeprazole

Esomeprazole vs Omeprazole: Overview

This comparison examines the pharmacological differences between Esomeprazole and Omeprazole.

Mechanism of Action

Esomeprazole: S-isomer of omeprazole; proton pump inhibitor irreversibly blocking gastric H+/K+-ATPase.

Omeprazole: Proton pump inhibitor that irreversibly blocks H+/K+-ATPase.

Pharmacokinetics

Half-life: Esomeprazole — 1-1.5 hours; Omeprazole — 0.5-1 hour.

Chemical Properties

Molecular Formula: Esomeprazole — C17H19N3O3S; Omeprazole — C17H19N3O3S.

Molecular Weight: Esomeprazole — 345.4170 g/mol; Omeprazole — 345.4170 g/mol.

Type: Esomeprazole — Small molecule; Omeprazole — Small molecule.