Fluconazole vs Tacrolimus

Fluconazole vs Tacrolimus: Overview

This comparison examines the pharmacological differences between Fluconazole and Tacrolimus.

Mechanism of Action

Fluconazole: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

Tacrolimus: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

Pharmacokinetics

Half-life: Fluconazole — 30 hours; Tacrolimus — 12 hours.

Chemical Properties

Molecular Formula: Fluconazole — C13H12F2N6O; Tacrolimus — C44H69NO12.

Molecular Weight: Fluconazole — 306.2710 g/mol; Tacrolimus — 804.0180 g/mol.

Type: Fluconazole — Small molecule; Tacrolimus — Small molecule.