Fluconazole vs Trimethoprim

Fluconazole vs Trimethoprim: Overview

This comparison examines the pharmacological differences between Fluconazole and Trimethoprim.

Mechanism of Action

Fluconazole: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

Trimethoprim: Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics

Half-life: Fluconazole — 30 hours; Trimethoprim — 8-10 hours.

Chemical Properties

Molecular Formula: Fluconazole — C13H12F2N6O; Trimethoprim — C14H18N4O3.

Molecular Weight: Fluconazole — 306.2710 g/mol; Trimethoprim — 290.3180 g/mol.

Type: Fluconazole — Small molecule; Trimethoprim — Small molecule.