Furosemide vs Spironolactone

Furosemide vs Spironolactone: Overview

This comparison examines the pharmacological differences between Furosemide and Spironolactone.

Mechanism of Action

Furosemide: Loop diuretic inhibiting Na-K-2Cl cotransporter.

Spironolactone: Mineralocorticoid receptor antagonist.

Pharmacokinetics

Half-life: Furosemide — 2 hours; Spironolactone — 1.4 hours.

Chemical Properties

Molecular Formula: Furosemide — C12H11ClN2O5S; Spironolactone — C24H32O4S.

Molecular Weight: Furosemide — 330.7440 g/mol; Spironolactone — 416.5740 g/mol.

Type: Furosemide — Small molecule; Spironolactone — Small molecule.