Gefitinib vs Imatinib

Gefitinib vs Imatinib: Overview

This comparison examines the pharmacological differences between Gefitinib and Imatinib.

Mechanism of Action

Gefitinib: Selective reversible inhibitor of EGFR tyrosine kinase.

Imatinib: Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.

Pharmacokinetics

Half-life: Gefitinib — 48 hours; Imatinib — 18 hours.

Chemical Properties

Molecular Formula: Gefitinib — C22H24ClFN4O3; Imatinib — C29H31N7O.

Molecular Weight: Gefitinib — 446.9000 g/mol; Imatinib — 493.6030 g/mol.

Type: Gefitinib — Small molecule; Imatinib — Small molecule.