Gefitinib vs Osimertinib

Gefitinib vs Osimertinib: Overview

This comparison examines the pharmacological differences between Gefitinib and Osimertinib.

Mechanism of Action

Gefitinib: Selective reversible inhibitor of EGFR tyrosine kinase.

Osimertinib: Third-generation irreversible EGFR TKI targeting T790M resistance mutation and activating mutations.

Pharmacokinetics

Half-life: Gefitinib — 48 hours; Osimertinib — 48 hours.

Chemical Properties

Molecular Formula: Gefitinib — C22H24ClFN4O3; Osimertinib — C28H33N7O2.

Molecular Weight: Gefitinib — 446.9000 g/mol; Osimertinib — 499.6050 g/mol.

Type: Gefitinib — Small molecule; Osimertinib — Small molecule.