Gefitinib vs Tofacitinib

Gefitinib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between Gefitinib and Tofacitinib.

Mechanism of Action

Gefitinib: Selective reversible inhibitor of EGFR tyrosine kinase.

Tofacitinib: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

Pharmacokinetics

Half-life: Gefitinib — 48 hours; Tofacitinib — 3.2 hours.

Chemical Properties

Molecular Formula: Gefitinib — C22H24ClFN4O3; Tofacitinib — C16H20N6O.

Molecular Weight: Gefitinib — 446.9000 g/mol; Tofacitinib — 312.3700 g/mol.

Type: Gefitinib — Small molecule; Tofacitinib — Small molecule.