Hydrochlorothiazide vs Lorazepam

Hydrochlorothiazide vs Lorazepam: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Lorazepam.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Lorazepam: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Lorazepam — 10-20 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Lorazepam — C15H10Cl2N2O2.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Lorazepam — 321.1580 g/mol.

Type: Hydrochlorothiazide — Small molecule; Lorazepam — Small molecule.