Hydrochlorothiazide vs Losartan

Hydrochlorothiazide vs Losartan: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Losartan.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Losartan: Angiotensin II receptor type 1 antagonist.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Losartan — 2 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Losartan — C22H23ClN6O.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Losartan — 422.9200 g/mol.

Type: Hydrochlorothiazide — Small molecule; Losartan — Small molecule.