Hydrochlorothiazide vs Metformin

Hydrochlorothiazide vs Metformin: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Metformin.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Metformin: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Metformin — 4-9 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Metformin — C4H11N5.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Metformin — 129.1640 g/mol.

Type: Hydrochlorothiazide — Small molecule; Metformin — Small molecule.