Hydrochlorothiazide vs Methotrexate

## Hydrochlorothiazide vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Methotrexate**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Methotrexate — C20H22N8O5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Methotrexate — Small molecule.