Hydrochlorothiazide vs Paroxetine

Hydrochlorothiazide vs Paroxetine: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Paroxetine.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Paroxetine: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Paroxetine — 21 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Paroxetine — C19H20FNO3.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Paroxetine — 329.3730 g/mol.

Type: Hydrochlorothiazide — Small molecule; Paroxetine — Small molecule.