Hydrochlorothiazide vs Sertraline

## Hydrochlorothiazide vs Sertraline: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Sertraline**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Sertraline**: Selective serotonin reuptake inhibitor (SSRI).

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Sertraline — 26 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Sertraline — C17H17Cl2N.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Sertraline — 306.2290 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Sertraline — Small molecule.