Hydrochlorothiazide vs Simvastatin

Hydrochlorothiazide vs Simvastatin: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Simvastatin.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Simvastatin: Prodrug converted to active form that inhibits HMG-CoA reductase.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Simvastatin — 2 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Simvastatin — C25H38O5.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Simvastatin — 418.5700 g/mol.

Type: Hydrochlorothiazide — Small molecule; Simvastatin — Small molecule.