Hydrochlorothiazide vs Trazodone

## Hydrochlorothiazide vs Trazodone: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Trazodone**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Trazodone**: Serotonin antagonist and reuptake inhibitor (SARI).

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Trazodone — 5-9 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Trazodone — C19H22ClN5O.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Trazodone — 371.8640 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Trazodone — Small molecule.