Hydroxychloroquine vs Methotrexate

## Hydroxychloroquine vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Hydroxychloroquine** and **Methotrexate**.

## Mechanism of Action

**Hydroxychloroquine**: Accumulates in lysosomes raising pH; inhibits toll-like receptor signaling.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Hydroxychloroquine — 40-50 days; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Hydroxychloroquine — C18H26ClN3O; Methotrexate — C20H22N8O5.

**Molecular Weight**: Hydroxychloroquine — 335.8720 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Hydroxychloroquine — Small molecule; Methotrexate — Small molecule.