Loratadine vs Tofacitinib

## Loratadine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Tofacitinib**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Tofacitinib — C16H20N6O.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Loratadine — Small molecule; Tofacitinib — Small molecule.