Lovastatin vs Spironolactone

## Lovastatin vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Lovastatin** and **Spironolactone**.

## Mechanism of Action

**Lovastatin**: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Lovastatin — 2-3 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Lovastatin — C24H36O5; Spironolactone — C24H32O4S.

**Molecular Weight**: Lovastatin — 404.5390 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Lovastatin — Small molecule; Spironolactone — Small molecule.