Methotrexate vs Vancomycin

## Methotrexate vs Vancomycin: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Vancomycin**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Vancomycin**: Glycopeptide antibiotic inhibiting cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan precursors.

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Vancomycin — 4-6 hours.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Vancomycin — C66H75Cl2N9O24.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Vancomycin — 1449.2500 g/mol.

**Type**: Methotrexate — Small molecule; Vancomycin — Small molecule.