Pravastatin vs Simvastatin

## Pravastatin vs Simvastatin: Overview

This comparison examines the pharmacological differences between **Pravastatin** and **Simvastatin**.

## Mechanism of Action

**Pravastatin**: Competitive inhibitor of HMG-CoA reductase.

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Pravastatin — 1.8 hours; Simvastatin — 2 hours.

## Chemical Properties

**Molecular Formula**: Pravastatin — C23H36O7; Simvastatin — C25H38O5.

**Molecular Weight**: Pravastatin — 424.5280 g/mol; Simvastatin — 418.5700 g/mol.

**Type**: Pravastatin — Small molecule; Simvastatin — Small molecule.