Prednisone vs Tofacitinib

## Prednisone vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Prednisone** and **Tofacitinib**.

## Mechanism of Action

**Prednisone**: Synthetic corticosteroid; suppresses inflammation via glucocorticoid receptor.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Prednisone — 2-3 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Prednisone — C21H26O5; Tofacitinib — C16H20N6O.

**Molecular Weight**: Prednisone — 358.4280 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Prednisone — Small molecule; Tofacitinib — Small molecule.