Sildenafil vs Sitagliptin

## Sildenafil vs Sitagliptin: Overview

This comparison examines the pharmacological differences between **Sildenafil** and **Sitagliptin**.

## Mechanism of Action

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

## Pharmacokinetics

**Half-life**: Sildenafil — 4 hours; Sitagliptin — 12.4 hours.

## Chemical Properties

**Molecular Formula**: Sildenafil — C22H30N6O4S; Sitagliptin — C16H15F6N5O.

**Molecular Weight**: Sildenafil — 474.5800 g/mol; Sitagliptin — 407.3140 g/mol.

**Type**: Sildenafil — Small molecule; Sitagliptin — Small molecule.