Sildenafil vs Sumatriptan

## Sildenafil vs Sumatriptan: Overview

This comparison examines the pharmacological differences between **Sildenafil** and **Sumatriptan**.

## Mechanism of Action

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

**Sumatriptan**: Selective 5-HT1B/1D receptor agonist.

## Pharmacokinetics

**Half-life**: Sildenafil — 4 hours; Sumatriptan — 2.5 hours.

## Chemical Properties

**Molecular Formula**: Sildenafil — C22H30N6O4S; Sumatriptan — C14H21N3O2S.

**Molecular Weight**: Sildenafil — 474.5800 g/mol; Sumatriptan — 295.4020 g/mol.

**Type**: Sildenafil — Small molecule; Sumatriptan — Small molecule.