Sildenafil vs Tofacitinib

## Sildenafil vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Sildenafil** and **Tofacitinib**.

## Mechanism of Action

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Sildenafil — 4 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Sildenafil — C22H30N6O4S; Tofacitinib — C16H20N6O.

**Molecular Weight**: Sildenafil — 474.5800 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Sildenafil — Small molecule; Tofacitinib — Small molecule.