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Acetohydroxamic Acid

CHEMBL734 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
75.1 g/mol
LogP
-1.6
Phase
4

A medication used to treat chronic urinary tract infections caused by bacteria that produce urease, an enzyme that breaks down urea and makes the urine alkaline, allowing kidney stones to form. By blocking urease, it prevents the bacteria from creating the alkaline environment they need to thrive and reduces the growth of certain types of kidney stones. It is typically used as a complement to antibiotics, not as a replacement, and requires monitoring for side effects including tremors and anemia.

Molekularmasse

75,0700 g/mol

LogP

-1,60

TPSA

49,30 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Tuberculosis

Wirkmechanismus

Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)NO

                

                

                
                

                    
InChI

                    
InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)

                

                

                

                    
                    

                        
Molecular Formula

                        
C2H5NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Rotierbare Bindungen

                        
0

                    

                    
                    
                    

                        
Schwere Atome

                        
5

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
A medication used to treat chronic urinary tract infections caused by bacteria that produce urease, an enzyme that breaks down urea and makes the urine alkaline, allowing kidney stones to form. By blocking urease, it prevents the bacteria from creating the alkaline environment they need to thrive and reduces the growth of certain types of kidney stones. It is typically used as a complement to antibiotics, not as a replacement, and requires monitoring for side effects including tremors and anemia.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Acetohydroxamic Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL734.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1990.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.