Aliskiren

CHEMBL1639 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

551.8 g/mol

LogP

3.5

Phase

4

A direct renin inhibitor that works at the very beginning of the renin-angiotensin-aldosterone system to reduce blood pressure, blocking the enzyme renin from initiating the cascade that leads to blood vessel constriction and sodium retention. It lowers blood pressure effectively and has been studied for its kidney-protective effects in patients with diabetes and hypertension.

Molekularmasse

551,8000 g/mol

LogP

3,50

TPSA

146,00 Å²

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Cardiovascular Disease Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Heart Failure Atrial Fibrillation

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

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SMILES

COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC

InChI

InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1

Molecular Formula

C30H53N3O6

HBD / HBA

4 / 7

Rotierbare Bindungen

19

Schwere Atome

39

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

A direct renin inhibitor that works at the very beginning of the renin-angiotensin-aldosterone system to reduce blood pressure, blocking the enzyme renin from initiating the cascade that leads to blood vessel constriction and sodium retention. It lowers blood pressure effectively and has been studied for its kidney-protective effects in patients with diabetes and hypertension.

Yes, Aliskiren is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1639. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5493444. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C30H53N3O6
Synonyme: 2

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.