Amdinocillin Pivoxil
The orally active pivaloyloxymethyl ester prodrug of amdinocillin that is absorbed from the gut and converted to the active antibiotic form in the body. This prodrug formulation allows the otherwise poorly orally absorbed amdinocillin to be taken by mouth for treating urinary tract infections caused by gram-negative bacteria.
Molekularmasse
439,6000 g/mol
LogP
3,10
TPSA
114,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C
InChI
InChI=1S/C21H33N3O5S/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23/h12,14-15,17H,6-11,13H2,1-5H3/b22-12+/t14-,15+,17-/m1/s1
Molecular Formula
C21H33N3O5S
HBD / HBA
- / 7
Rotierbare Bindungen
8
Schwere Atome
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
The orally active pivaloyloxymethyl ester prodrug of amdinocillin that is absorbed from the gut and converted to the active antibiotic form in the body. This prodrug formulation allows the otherwise poorly orally absorbed amdinocillin to be taken by mouth for treating urinary tract infections caused by gram-negative bacteria.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Amdinocillin Pivoxil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1650818. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 115163. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="amdinocillin-pivoxil"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/amdinocillin-pivoxil/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/amdinocillin-pivoxil/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/amdinocillin-pivoxil/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="amdinocillin-pivoxil"></drugfyi-drug>