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Azathioprine

CHEMBL1542 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
277.3 g/mol
LogP
0.1
Phase
4

An immunosuppressant prodrug that is converted in the body to 6-mercaptopurine, which interferes with DNA synthesis in rapidly dividing immune cells, reducing the immune response. It is used to prevent organ transplant rejection and to treat autoimmune conditions.

Molekularmasse

277,2700 g/mol

LogP

0,10

TPSA

143,00 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Rheumatoid Arthritis Inflammatory Bowel Disease Psoriasis Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Atopic Dermatitis Gout Heart Failure Cardiovascular Disease

Wirkmechanismus

Suppresses the immune system by inhibiting T-cell activation, lymphocyte proliferation, or cytokine production. This prevents immune-mediated tissue damage and graft rejection.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Suppresses the immune system by inhibiting T-cell activation, lymphocyte proliferation, or cytokine production. This prevents immune-mediated tissue damage and graft rejection.

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cn1cnc([N+](=O)[O-])c1Sc1ncnc2[nH]cnc12

                

                

                
                

                    
InChI

                    
InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H7N7O2S

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
Rotierbare Bindungen

                        
2

                    

                    
                    
                    

                        
Schwere Atome

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
An immunosuppressant prodrug that is converted in the body to 6-mercaptopurine, which interferes with DNA synthesis in rapidly dividing immune cells, reducing the immune response. It is used to prevent organ transplant rejection and to treat autoimmune conditions.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Suppresses the immune system by inhibiting T-cell activation, lymphocyte proliferation, or cytokine production. This prevents immune-mediated tissue damage and graft rejection.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Azathioprine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1542.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2265.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.