Baricitinib
A JAK1/JAK2 inhibitor that blocks the intracellular signaling pathways that drive inflammation in conditions such as rheumatoid arthritis and atopic dermatitis. It is taken by mouth once daily.
Molekularmasse
371,4170 g/mol
LogP
-0,50
TPSA
129,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Arzneimittelklassen
Wirkmechanismus
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1
InChI
InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
Molecular Formula
C16H17N7O2S
HBD / HBA
1 / 7
Rotierbare Bindungen
5
Schwere Atome
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A JAK1/JAK2 inhibitor that blocks the intracellular signaling pathways that drive inflammation in conditions such as rheumatoid arthritis and atopic dermatitis. It is taken by mouth once daily.
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Key pharmacokinetic parameters for Baricitinib: Half-life: 12 hours.
Yes, Baricitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105759. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44205240. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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