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Bendamustine Hydrochloride

CHEMBL1201734 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
394.7 g/mol
LogP
—
Phase
4

The hydrochloride salt of bendamustine, the commercially available formulation of this bifunctional alkylating agent. It is given intravenously and retains efficacy in some cancers resistant to other alkylating agents.

Molekularmasse

394,7000 g/mol

TPSA

58,40 Ų

Therapeutische Bereiche

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Wirkmechanismus

Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cl.Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H22Cl3N3O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Rotierbare Bindungen

                        
9

                    

                    
                    
                    

                        
Schwere Atome

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
The hydrochloride salt of bendamustine, the commercially available formulation of this bifunctional alkylating agent. It is given intravenously and retains efficacy in some cancers resistant to other alkylating agents.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Bendamustine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201734.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 77082.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.