Berotralstat

CHEMBL5189739 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

562.6 g/mol

LogP

4.5

Phase

4

An oral medication used to prevent recurrent attacks of hereditary angioedema, a rare condition causing episodes of severe swelling. It works by inhibiting plasma kallikrein, an enzyme responsible for triggering the swelling episodes. Unlike injectable treatments, its oral administration offers convenience for long-term prevention.

Molekularmasse

562,6000 g/mol

LogP

4,50

TPSA

109,00 Å²

Lipinski-Regel der Fünf

Bestanden

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

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SMILES

N#Cc1cccc([C@@H](NCC2CC2)c2ccc(F)c(NC(=O)c3cc(C(F)(F)F)nn3-c3cccc(CN)c3)c2)c1

InChI

InChI=1S/C30H26F4N6O/c31-24-10-9-22(28(37-17-18-7-8-18)21-5-1-3-19(11-21)15-35)13-25(24)38-29(41)26-14-27(30(32,33)34)39-40(26)23-6-2-4-20(12-23)16-36/h1-6,9-14,18,28,37H,7-8,16-17,36H2,(H,38,41)/t28-/m1/s1

Molecular Formula

C30H26F4N6O

HBD / HBA

3 / 9

Rotierbare Bindungen

9

Schwere Atome

41

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

An oral medication used to prevent recurrent attacks of hereditary angioedema, a rare condition causing episodes of severe swelling. It works by inhibiting plasma kallikrein, an enzyme responsible for triggering the swelling episodes. Unlike injectable treatments, its oral administration offers convenience for long-term prevention.

Yes, Berotralstat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5189739. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 137528262. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C30H26F4N6O
Synonyme: 1

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.