Boceprevir
A direct-acting antiviral that inhibits the NS3/4A protease enzyme of the hepatitis C virus, blocking viral replication. It was used as part of triple therapy for chronic hepatitis C genotype 1 infection. It has been largely replaced by newer, more effective and better-tolerated all-oral direct-acting antiviral regimens.
Molekularmasse
519,7000 g/mol
LogP
3,10
TPSA
151,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Inhibits viral protease enzymes required for the cleavage of polyprotein precursors into functional viral proteins, blocking viral maturation and replication.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease enzymes required for the cleavage of polyprotein precursors into functional viral proteins, blocking viral maturation and replication.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CC(C)(C)NC(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C)C(C)(C)C
InChI
InChI=1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31-26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(19(33)21(28)34)12-14-10-9-11-14/h14-18,20H,9-13H2,1-8H3,(H2,28,34)(H,29,35)(H2,30,31,37)/t15-,16?,17-,18-,20+/m0/s1
Molecular Formula
C27H45N5O5
HBD / HBA
4 / 5
Rotierbare Bindungen
10
Schwere Atome
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A direct-acting antiviral that inhibits the NS3/4A protease enzyme of the hepatitis C virus, blocking viral replication. It was used as part of triple therapy for chronic hepatitis C genotype 1 infection. It has been largely replaced by newer, more effective and better-tolerated all-oral direct-acting antiviral regimens.
Inhibits viral protease enzymes required for the cleavage of polyprotein precursors into functional viral proteins, blocking viral maturation and replication.
Yes, Boceprevir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL218394. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10324367. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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