Buspirone Hydrochloride

CHEMBL1200399 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

422.0 g/mol

LogP

—

Phase

4

The hydrochloride salt of buspirone, used for generalized anxiety disorder without the sedative or dependence-causing properties of benzodiazepines. It is taken multiple times daily and requires consistent use over weeks for full benefit. It does not provide immediate relief and is not suitable for as-needed anxiety treatment.

Molekularmasse

422,0000 g/mol

TPSA

69,60 Å²

Therapeutische Bereiche

Parkinson's Disease Epilepsy Schizophrenia Generalized Anxiety Disorder Gastroesophageal Reflux Disease Stroke Major Depressive Disorder Heart Failure

Wirkmechanismus

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …

2D-Struktur

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SMILES

Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1

InChI

InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

Molecular Formula

C21H32ClN5O2

HBD / HBA

1 / 6

Rotierbare Bindungen

6

Schwere Atome

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

The hydrochloride salt of buspirone, used for generalized anxiety disorder without the sedative or dependence-causing properties of benzodiazepines. It is taken multiple times daily and requires consistent use over weeks for full benefit. It does not provide immediate relief and is not suitable for as-needed anxiety treatment.

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

Yes, Buspirone Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200399. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 36431. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C21H32ClN5O2
Synonyme: 4

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.