Cefotaxime
A third-generation cephalosporin antibiotic with broad-spectrum activity against gram-negative bacteria and many gram-positive organisms, widely used for meningitis, sepsis, and serious respiratory and urinary tract infections. It penetrates the blood-brain barrier effectively, making it valuable in central nervous system infections. It is metabolized to desacetylcefotaxime, which retains some antibacterial activity.
Molekularmasse
455,5000 g/mol
LogP
-1,40
TPSA
227,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1csc(N)n1
InChI
InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1
Molecular Formula
C16H17N5O7S2
HBD / HBA
3 / 12
Rotierbare Bindungen
8
Schwere Atome
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A third-generation cephalosporin antibiotic with broad-spectrum activity against gram-negative bacteria and many gram-positive organisms, widely used for meningitis, sepsis, and serious respiratory and urinary tract infections. It penetrates the blood-brain barrier effectively, making it valuable in central nervous system infections. It is metabolized to desacetylcefotaxime, which retains some antibacterial activity.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cefotaxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1730. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5742673. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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