Clobazam
A benzodiazepine anticonvulsant that enhances the inhibitory neurotransmitter GABA to reduce seizure frequency, approved as an add-on therapy for Lennox-Gastaut syndrome. It also has anxiolytic properties and is used in some countries for short-term anxiety relief.
Molekularmasse
300,7400 g/mol
LogP
2,10
TPSA
40,60 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
2D-Struktur
Cite this structure
Embed this structure
SMILES
CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
Molecular Formula
C16H13ClN2O2
HBD / HBA
- / 2
Rotierbare Bindungen
1
Schwere Atome
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A benzodiazepine anticonvulsant that enhances the inhibitory neurotransmitter GABA to reduce seizure frequency, approved as an add-on therapy for Lennox-Gastaut syndrome. It also has anxiolytic properties and is used in some countries for short-term anxiety relief.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Clobazam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL70418. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2789. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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