Darunavir
A second-generation HIV protease inhibitor that prevents viral replication by blocking the enzyme that cleaves HIV polyproteins into functional components, always used boosted with cobicistat or ritonavir. It has a high barrier to resistance and remains active against many PI-resistant viral strains.
Molekularmasse
547,7000 g/mol
LogP
2,90
TPSA
149,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1
InChI
InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1
Molecular Formula
C27H37N3O7S
HBD / HBA
3 / 9
Rotierbare Bindungen
12
Schwere Atome
38
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A second-generation HIV protease inhibitor that prevents viral replication by blocking the enzyme that cleaves HIV polyproteins into functional components, always used boosted with cobicistat or ritonavir. It has a high barrier to resistance and remains active against many PI-resistant viral strains.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Darunavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1323. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 213039. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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