Dextromethorphan
A synthetic opioid analogue without analgesic properties that suppresses cough by acting on sigma receptors and NMDA receptors in the brain stem, widely used as an over-the-counter antitussive. At high doses it can cause dissociative hallucinations and is subject to misuse.
Molekularmasse
271,4000 g/mol
LogP
3,40
TPSA
12,50 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
2D-Struktur
Cite this structure
Embed this structure
SMILES
COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
InChI
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
Molecular Formula
C18H25NO
HBD / HBA
- / 2
Rotierbare Bindungen
1
Schwere Atome
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A synthetic opioid analogue without analgesic properties that suppresses cough by acting on sigma receptors and NMDA receptors in the brain stem, widely used as an over-the-counter antitussive. At high doses it can cause dissociative hallucinations and is subject to misuse.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Dextromethorphan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL52440. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5360696. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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