Diclofenac
A widely used NSAID that inhibits both COX-1 and COX-2 enzymes to reduce prostaglandin synthesis, providing anti-inflammatory, analgesic, and antipyretic effects for conditions including arthritis, acute pain, and dysmenorrhea. It is available in oral, topical, and injectable formulations.
Molekularmasse
296,1000 g/mol
LogP
4,40
TPSA
49,30 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
2D-Struktur
Cite this structure
Embed this structure
SMILES
O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl
InChI
InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
Molecular Formula
C14H11Cl2NO2
HBD / HBA
2 / 3
Rotierbare Bindungen
4
Schwere Atome
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A widely used NSAID that inhibits both COX-1 and COX-2 enzymes to reduce prostaglandin synthesis, providing anti-inflammatory, analgesic, and antipyretic effects for conditions including arthritis, acute pain, and dysmenorrhea. It is available in oral, topical, and injectable formulations.
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Yes, Diclofenac is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL139. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3033. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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