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Etrasimod

CHEMBL3358920 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
457.5 g/mol
LogP
6.4
Phase
4

This oral medication selectively binds to sphingosine-1-phosphate receptors, keeping certain white blood cells in the lymph nodes so they cannot travel to sites of inflammation in the gut. It is used to treat moderately to severely active ulcerative colitis.

Molekularmasse

457,5000 g/mol

LogP

6,40

TPSA

62,30 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Inflammatory Bowel Disease Atopic Dermatitis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(O)C[C@H]1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21

                

                

                
                

                    
InChI

                    
InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H26F3NO3

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
Rotierbare Bindungen

                        
6

                    

                    
                    
                    

                        
Schwere Atome

                        
33

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
This oral medication selectively binds to sphingosine-1-phosphate receptors, keeping certain white blood cells in the lymph nodes so they cannot travel to sites of inflammation in the gut. It is used to treat moderately to severely active ulcerative colitis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Etrasimod is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3358920.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 44623998.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.